St. Alphonsa was born on 19th August 1910 at Kudamaloor in Kerala. In her childhood itself she was inspired by the life and spirituality of St. Theresa of Liseux and desired to become an nun. Being exceptionally charming she had to brush aside many proposals of marriage before her joining the Clarist convent at bharananganam in Kerala. Cherishing in her heart a deep desire to become a saint. She received the habit (nun's dress) of the congregation in 1930. Then for some time she served in the school at Vakakkadu as teacher. She was very much fond of children and mingled with each and everyone of them imparting the tender love of Jesus. St. Alphonsa was very sweet in her behavior and very much liked by her pupils.
The period 1930–1935 was characterised by grave illness. Alphonsa took her permanent vows on 12 August 1936.Two days later she returned to Bharananganam from Changanacherry. She then taught high school at St. Alphonsa Girl's High School, but was often sick and unable to teach. For most of her years as a Clarist sister she endured serious illness.